DNA Nanotetrahedra for drug delivery - Isis Project No 2805

Novel drug delivery platform technology based on new DNA nanostructural cages.

MARKETING OPPORTUNITY

A DNA cage system has been developed with potential for application in drug targeting and drug delivery.  The DNA cages combine the functions of sensor and delivery vehicle and open the way for a new generation of ‘smart’ drug-delivery technologies.

THE OXFORD INVENTION

 Self-assembling DNA cages have been developed that can be formed into a number of useful shapes including tetrahedra. The ability to be able to incorporate a significantly sized bio-molecule has been demonstrated with Cytochrome C, amongst others.  The shape can be tailored to allow the incorporation of differently shaped and / or sized molecules.

Once a drug, marker or other molecule of interest has been incorporated into the cage, it can be targeted to a tissue of interest by the addition of a signal molecule, or the ligand of a receptor found only on the tissue or cell type of interest. Adding a ligand to a tissue specific receptor involves a relatively simple synthetic step, and opens the possibility of getting relatively large molecules and nano-medicines across biological barriers, such as the gastrointestinal tract. Release of the payload may then be accomplished through the presence or action of a selected molecule or chemical environment.

Chemically, these cages are stereo-pure, rigid and adaptable. Crucially, they are simple to assemble, in a single step with a yield of approximately 95%.  Importantly for a potential targeted drug delivery technology, they are robust and stable, and are cost efficient in comparison to other DNA technologies.

PATENT STATUS

Isis Innovation has applied for a patent covering this invention.  This is a fast moving and exciting area of research and development and with the plethora of potential for this technology to be tailored to a company’s specific requirements, licensees are sought who have an interest in co-development. . Please contact Dr David Phillips, Project Manager, at Isis Innovation Ltd. to discuss this further.

Request Further Information: Project Number 3805 DNA Nanotetrahedra for drug delivery