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Technology Transfer from the University of Oxford

Surface Tension - Isis Project No 757

This invention describes a novel method for the indirect measurement of surface tension by means of surface configuration assessment. The procedure is reliable, repeatable and quick to set-up and use. In addition it is contactless and non-destructive.

Background

Surface tension measurement is an important tool in the characterisation of surface-active liquids and mixtures. There are currently a number of well-established techniques which are used commercially.

Problem

Although precise, the traditional measuring methods suffer from several problems. The volume of sample required may be many millilitres; sample recovery may be difficult or impossible. Furthermore, existing methods are usually time-consuming, manual, difficult to automate and unsuitable for hazardous samples.

The Oxford Invention

A research group at the University of Oxford has developed a novel method of measuring the surface tension of liquid utilising a multiwell plate reader. The invention is based upon the effect of variation of reflected or transmitted light intensity as a function of the angle of incidence of light on a sample's surface. This will provide a measurement of the surface configuration and hence surface tension.

The method improves on current techniques in several commercially relevant areas:

  • Reduced sample size - microlitres vs. millilitres.
  • Reduced measurement time - milliseconds vs. minutes per sample.
  • High throughput for samples arrayed on 96 well microplates.
  • Sensitivity - surface active detergent can be detected down to 1ppm.
  • Facile automation leading to remote handling of toxic/infectious materials.
  • Possible adaptation to incorporate atmospheric (pressure/gas) changes.

This technology will be potentially interesting to the multiwell plate reader business, manufacturers of surface tension measuring equipment and the surfactant/detergent industry. In addition, the standard usage of plate readers in the biotechnology industry may also be improved.

Commercialisation

This discovery is subject to a patent application. Isis Innovation is interested in discussing suitable arrangements with companies able to utilise this technology.

Request Further Information: Project Number 757 - Surface Tension