Patient Reported Outcomes from the University of Oxford

PDQ recommended in a review of Parkinson’s Disease Health-Related Quality-of-Life Measures

23 December 2011

In a recent publication1 that reviewed available Health-related quality of Life (HRQoL) measures for Parkinson’s Disease (PD), the PDQ successfully achieved “recommended” status and was cited as being the most thoroughly tested and applied questionnaire for the condition. The authors of the paper consisted of an international team of 13 PD experts (making up a Movement Disorder Society Task Force) specifically commissioned to rate the psychometric quality of available health-related quality of life scales as applied to Parkinson’s disease.

Four generic and 5 condition specific scales were assessed in the study including the PDQ-39 and the short-form PDQ-8 which both achieved the highest classification of “recommended”.

The PDQ is the most widely used condition-specific HRQoL for Parkinson’s Disease and has been shown to be particularly appropriate for use in clinical trial to assess treatments and interventions intended to benefit individuals with Parkinson’s Disease. The PDQ has been used in many clinical trials as both a primary and secondary outcome measure.

Isis Outcomes supports the use of the PDQ from study planning, PRO preparation (such as ensuring language requirements are satisfied for the study territories), PRO deployment and scoring, to PRO evidence dossiers.

1Martinez-Martin P., Jeukens-Visser M., Lyons K., Rodriguez-Blazquez C., Selai C., Siderowf A., Welsh M., Poewe W., Rascol O., Sampaio C., Stebbins G., Goetz C., Schrag A. Health-Related Quality-of-Life Scales in Parkinson’s Disease: Critique and Recommendations. Movement Disorders, Vol. 26, No. 13, 2011.